The research goal of the Clinical Neurophysiology Research Laboratory is to further understand the neurophysiology of psychosis. Brain activity measures span simple sensory and perceptual processes to complex higher-order cognition. Dysfunction in local circuit activity, reflected in sensory processing deficits, and in long-range distributed cortical processing, reflected in deficits in the interplay between semantic memory neural storage networks and working memory systems that allow adaptive and flexible human behavior in the face of unique current situations, are the main areas of inquiry by which our team attempts to detect the underlying brain abnormalities giving rise to psychosis. Understanding of the basic dysfunctions, in turn, will lead to earlier identification, better interventions, and improved outcome in schizophrenia and other psychotic disorders.