Current Research

Auditory Cortex Connectivity in Emerging Psychosis

R01 MH113533
Principal Investigator: DF Salisbury
Project period: 9/15/2017 – 6/30/2022
Sponsor: NIMH
Purpose:This project aims to understand the neurobiology of verbal auditory hallucinations by examining structure and function in a left-hemisphere dominant language circuit thought to be involved in the genesis of verbal auditory hallucinations cross-diagnostically during initial stages of psychosis comprising the clinical high risk stage, the first psychotic episode stage, and longitudinally into the early psychosis stage.

Mismatch Negativity and Complex Second-Order Sensory Memory in Schizophrenia

R01 MH094328
Principal Investigator: DF Salisbury
Project period: 5/1/2012 – 4/30/2017
Sponsor: NIMH
Purpose: To investigate complex acoustic pattern analysis and echoic memory abnormalities in schizophrenia utilizing electrophysiological measures, and compare and contrast these dysfunctions with control subjects to provide novel measures of brain dysfunction.

Cortical Cells, Circuits, Connectivity and Cognition in Schizophrenia

P50 MH103204
Principal Investigator: DA Lewis
Project Period: 4/1/2014 – 3/31/2019
Sponsor: NIMH
Project 5 Co-Principal Investigators: B Luna & DF Salisbury
Project 5 Title: Alterations of Cortical Connectivity and Cognition in Schizophrenia
Purpose: To determine how basic cellular and circuit abnormalities identified in post-mortem and animal model work (Projects 1 – 4) give rise to cortical network and cognitive disturbances in medication naïve, first-episode psychosis.

Auditory Attention in First Episode Psychosis

R01 MH108568
Principal Investigator: DF Salisbury
Project Period: 8/19/2016 – 5/31/2021
Sponsor: NIMH
Purpose: This project will develop inexpensive biomarkers of auditory sensory and executive attention processes while providing novel understanding of the way prefrontal, parietal, and sensory cortices communicate in the service of selective attention, and how such processes go awry as psychosis emerges.