Effective Connectivity in First Psychosis
R01 MH126951
Principal Investigator: DF Salisbury
Project Period: 7/1/2022 – 6/30/2027
Sponsor: NIMH
Purpose: This project aims to examine effective connectivity between nodes of the temporal lobe auditory cortices and the inferior frontal gyrus auditory-executive cortex involved in the generation of mismatch negativity (MMN), an index of automatic auditory change detection. This will be done through the use of computational modeling to translate neurophysiological information from EEG & MEG to synaptic conductances, indicating possible molecular mechanisms of the systems-level deficits.
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Visual Network Connectivity and Perceptual Modulation in Early Psychosis
KA Award
Principal Investigator: AL Sklar
Project Period: 4/1/2022 – 3/31/2027
Sponsor: NIH
Purpose: This project will examine the neural basis of visual perceptual modulation using multimodal imaging (MRI, EEG, and MEG) and its association with clinical impairment at first-episode psychosis to inform targeted treatment approaches.
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Targeting the Auditory Control Network with Auditory Control Enhancement (ACE) in Schizophrenia
R21
Principal Investigator: BA Coffman
Project Period: 9/1/2022 – 8/31/2024
Sponsor: NIMH
Purpose: This study will investigate neural markers of target engagement to further develop auditory control enhancement (ACE) as a novel, inexpensive, and noninvasive intervention to address treatment-refractory auditory hallucinations in schizophrenia.
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