Dean F. Salisbury, PhD
Associate Professor of Psychiatry
Dr. Salisbury, Associate Professor of Psychiatry, is the Director of the Clinical Neurophysiology Research Laboratory. He earned his doctorate degree in Biological Psychology at the State University of New York at Stony Brook and completed a clinical research training fellowship focusing in Neuropsychiatry at the Harvard Medical School. Dr Salisbury spent the last 20 years at McLean Hospital and Harvard Medical School studying the neurophysiology of psychosis.
Dr. Salisbury’s research interests focus on schizophrenia pathophysiology and human electrophysiology. He utilizes electrophysiology and multimodal brain imaging to examine thought disturbance (cognitive-level) and basic auditory processing abnormalities (sensory-level) in psychosis, and specializes in event-related potential recordings in humans. Dr. Salisbury has also collaborated extensively with colleagues using magnetic resonance imaging and functional magnetic resonance imaging methods on a number of research projects.
The goal of Dr. Salisbury’s work is to further understand the neurophysiology of psychosis. Brain activity measures span simple sensory and perceptual processes to complex higher-order cognition. Dysfunction in local circuit activity, reflected in sensory processing deficits, and in long-range distributed cortical processing, reflected in deficits in the interplay between semantic memory neural storage networks and working memory systems that allow adaptive and flexible human behavior in the face of unique current situations, are the main areas of inquiry by which Dr. Salisbury and his team try to detect the underlying brain abnormalities giving rise to psychosis. Understanding of the basic dysfunctions, in turn, will lead to earlier identification, better interventions, and improved outcome in schizophrenia and other psychotic disorders.
Sarah M. Haigh, PhD
I am a post-doctoral associate in the Clinical Neurophysiology Research Lab (CNRL). I grew up in the UK and moved to Pittsburgh January 2013. I completed my BSc at the University of Bristol in Experimental Psychology, and my PhD in Sensory Neuroscience at the University of Essex under the supervision of Prof. Arnold Wilkins. My first post-doctoral position was at Carnegie Mellon University, Pittsburgh, with Dr. Marlene Behrmann and Dr. David Heeger (New York University) to work on the neurological correlates of autism using individuals with schizophrenia as a comparison group. I also completed two study visits during my PhD to York University with Dr. Frances Wilkinson, and to the Institute für Arbeitsforschung, Dortmund, Germany, with Dr. Wolfgang Jaschinski.
My main research interests focus on physiological responses to basic sensory stimuli, and specifically what drives the system to over-respond (hyper-excitable) or under-respond (hypo-excitable). I am interested in what this can reveal 1) about certain clinical conditions, for example, schizophrenia, autism, migraine or photosensitive epilepsy, and 2) about early sensory processing in non-clinical individuals. By measuring the correlation between behavioral and cortical responses, potential early diagnosis biomarkers can be identified and monitored for impairments or improvements in sensory processing in clinical conditions.
I have used a mixture of techniques to measure sensory sensitivities, including psychophysics, the electroencephalogram (EEG), near-infrared spectroscopy (NIRS), EEG and NIRS simultaneously, functional magnetic resonance imaging (fMRI), and the auto-refractor (to measure ocular accommodation). My PhD focused on visual processing, but my first post-doctoral position at Carnegie Mellon included auditory and somatosensory processing.
Brian Coffman, PhD
Dr. Brian Coffman is a post-doctoral associate in the Clinical Neurophysiology Research Lab (CNRL). He earned his BS, MS, and Ph.D. in Psychology at the University of New Mexico, where his primary mentor was Dr. Vincent P. Clark. Dr. Coffman has been involved with neuroimaging and cognitive neuroscience research since 2007, when joined the Mind Research Network in Albuquerque, New Mexico.
Dr. Coffman’s current research interests include cognitive neuroscience, clinical neuroimaging, brain stimulation, and neuroinformatics. In particular, he has pursued interests in functional magnetic resonance imaging (fMRI), electroencephalography (EEG), magnetoencephalography (MEG), transcranial direct current stimulation (tDCS), and mathematical/computational problems associated with neuroimaging data analysis. Dr. Coffman has published basic science research as well as research in various clinical populations, and he has applied multimodal neuroimaging data to complex problems in clinical diagnosis and treatment. Dr. Coffman’s current research examines sensory and perceptual electrophysiological processes in Schizophrenia patients in an effort to further understand the neurophysiology of psychosis, and aid in earlier diagnosis and better treatment interventions for this unfortunate population.
Tim K. Murphy, BS
Research Project Manager
I received my Bachelor of Science in Psychology with a minor in neuroscience at the University of Pittsburgh. After graduating in April 2012, I began working in the Clinical Neurophysiology Research Lab. One day I hope to go onto graduate school to study Cognitive Neuroscience and, more specifically, how the brain learns to categorize phonemes through statistical regularities in speech sounds. I am also very interested in predictive processes occurring in the brain and how they unfold over time. Of particular interest to me is the contribution of the basal ganglia and cerebellum to these processes. I hope to answer these questions using a combination of computational, behavioral, and physiological methods.
Justin Leiter-McBeth, BS
In 2012 I moved to Kent, OH to attend Kent State University where I received a Bachelor of Science in Psychology. I volunteered in different labs during my undergrad focusing on child attachment, mindfulness, and mood disorders. I also worked as a neurofeedback (EEG biofeedback) technician during my senior year. I joined the Clinical Neurophysiology Research Lab in the summer of 2016. I plan on attending graduate school in the future to pursue a doctorate degree in Clinical Neuropsychology. I am interested in psychosis, autism, mood disorders, as well as mindfulness based therapies and techniques.
Undergraduates (Summer 2017)
Rising Senior – University of Pittsburgh
My role in the CNRL lab is to help analyze the data collected for a study that compares the sensory responses of first episode psychosis patients to healthy controls. Participants go through a variety of auditory tests that are able to gauge attention deficits through an EEG. The goal of the study is to determine a potential diagnostic tool that recognizes schizophrenia early enough to allow for preventative treatments.
Rising Sophmore – Carnegie Mellon University
At CNRL I will be programming a protocol to study implicit categorical learning for schizophrenia with the Systematic Multimodal Associations Reaction Time (SMART) task and EEG. I will look at the relationship between visuomotor dimensions and auditory categories.